Start studying drugs affecting the hematopoietic system. The hematopoietic system consists of a complex network of. In the hematopoietic system, entps can act at different levels. In a model of nmdaantagonist mk801induced drug toxicity, repo conferred 50%. Be able to diagram the coagulation and fibrinolytic pathways and the interaction. Nonetheless, these cells have one feature in common. Antihypertensive drugs and the sympathetic nervous system. Identify common clinical manifestations of inadequate erythropoiesis and diminished host defense mechanisms. The main drugs that have been clearly shown to affect sns function are betablockers, alphablockers, and centrally acting drugs. Epoetin alfa epogen, procritepoetin alfa stimulates the division and. Hematopoietic colonystimulating factors csfs medicare. The clinical benefit of erythropoiesisstimulating drug therapy is to reduce the cost of blood transfusions, lessen the risk of infectious diseases from. Toxins drugs antineoplastic immunosuppressive drugs idiosyncratic drug reactions toxic chemicals infectious agents feline and canine parvovirus felv. The areas covered in this discussion include hematopoiesis, functions of the various hematopoietic organs and tissues as well as the blood cells.
A coagulant is a drug that stimulates the clotting of the blood. It is uniquely constructed to provide the body with a vast capacity for cell renewal. Erythrocyte factors are subsequently divided into nutrients such as iron or vitamins and erythropoietin, a growth factor that stimulates erythrocyte formation. Recombinant human gcsf is a hematopoietic growth factor, extensively used in cancer therapy to. Drugs for treatment of megaloblastic macrocytic, hyperchromic anemias vitamin b12 cyanocobalamin amp. Oral ingestion or snorting produces a longlasting high instead of a rush.
Kidney dysfunction after hematopoietic cell transplantation. Dec 01, 2018 ongoing studies focus on a nephroprotective role of drugs acting on the reninangiotensinaldosterone system in patients after tbi or taking cnis. The process is regulated in part by hematopoietic growth factorsnaturally occurring hormones that stimulate the proliferation and differentiation of hematopoietic stem cells, and enhance function in the mature forms of those cells. Drugs that stimulate the immune system to produce blood cells are hematopoietic growth factors. Csf produced by recombinant dna technology in a yeast s. Drugs acting on the immune system the immune system discriminates self from nonself allowing it to destroy infectious invaders or tumors while leaving normal cells intact. Class ia drugs increase, class ib decrease while class. Haemopoietic systeminfections hepatitis cmv, ebv, herpes vinherited fanconis anaemia. Mechanism revealed for side effects of drug used in hematopoietic stem cell harvesting. Hematopoietic drugshematopoietic drugs introduction hematopoiesis formation of blood is a complex process of proliferation, differentiation, and maturation of cellular components of blood erythrocytes, leucocytes and platelets from the bone marrow stem cells. Special compartments several special compartments deserve mention.
A single stem cell can sustain the entire hematopoietic system for the lifetime of a mouse in certain experimental systems. The rise and fall of the import drug act of 1848, food and drug law journal, vol. Hematopoietic drugs on medindia find the complete list of hematopoietic drugs with their available forms and strength. Hematopoietic stem cell transplantation hsct is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood. It became apparent that in these in vitro systems, a single bone. Used for mobilization of hematopoietic progenitor cells into the peripheral blood for collection by leukapheresis. Discuss characteristics of hematopoietic drugs in terms of the prototype, mechanism of action, indications for use, adverse effects, principles of therapy, and nursing implications. Two components, innate and adaptive provide an early active response and an antigenspecific response, respectively. Hematopoietic growth factor an overview sciencedirect topics. Sharon gwaltneybrant, in biomarkers in toxicology, 2014. She would joke that, since her dog died, her only exercise was walking back and forth to her car. Loss of hematopoietic precursors can result in deficiencies of their. Drugs used in medicine generally are divided into classes or groups on the basis of their uses, their chemical structures, or their mechanisms of action.
Dec 08, 2014 drugs acting on hematopoietic system 001. Feb 28, 2011 flow cytometry is an essential tool for dissecting the functional complexity of hematopoiesis. Hematopoietic growth factors regulate proliferation and differentiation of all stages. Drug classes presented in this chapter include nutrients and growth factors affecting formation of blood. In very severe cases, allogeneic hematopoietic stem cell transplantation may be considered.
Drugs used in the treatment of altered hemostasis can be divided into those that inhibit thrombosis and those that facilitate clotting. As with epor, gcsf receptor expression is not limited to the hematopoieti. Knych, principles, and types of biological variability dr. Drugs that stimulate production of rbcs are erythropoietics, those that produce wbcs are colonystimulating factors, and those that increase platelets include a special interleukin. Hematopoiesis is the process by which our bodies make red blood cells, white blood cells, and platelets. The hematopoietic system is composed of a wide range of lymphoid tissues and all the fixed and circulating blood cells originating from pluripotent precursors cells in the bone marrow. A doctor or other trained health professional will give you hematopoietic progenitor cells, cord blood in a hospital. Those who smoke or inject it report a brief, intense sensation, or rush. Hematopoietic colonystimulating factors csfs medical. Now, before we discuss these medications in detail, let. More information is available on each drug including their price list. Hematopoietic medications increase the amount of blood cells. Allogeneic hematopoietic transplantation for multiple myeloma in the new drugs era. Degeneration and necrosis radiation toxins drugs antineoplastic immunosuppressive drugs idiosyncratic drug reactions toxic chemicals infectious agents feline and canine parvovirus felv fiv eia immunemediated sle.
This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Early stage rectal cancer soft tissue sarcoma squamous cell skin cancer stomach cancer survivorship care for cancerrelated late and longterm effects survivorship care. Mechanism revealed for side effects of drug used in. Cns drugs central acting antiadrenergics nursing management do not stop taking the drug abruptly, except on the advice of the primary health care provider. The hematopoietic factors are initially classified based on the blood component stimulated. A platform to cure alberto mussetti 1,2, maria queralt salas 1,2 and vittorio montefusco 3 1 clinical hematology department, institut catala doncologiahospitalet, 089080 barcelona, spain. Pdf important drug interactions in hematopoietic stem cell.
The signaling behavior of cell subsets spanning a defined hematopoietic hierarchy was. Dec 14, 2012 haemopoietic system metabolic defects g6pd deficiency pk deficiency hb defects quantitaive defects thalassaemias qualitative defects sickle cell anaemia hbc, d, e unstable hb 14. Drugs acting on the blood or bloodforming organs pharmacology. Hematopoietic system an overview sciencedirect topics. The name of benralizumab, a drug designed for the treatment of asthma, has the components benralizumab, marking it as a humanized antibody acting on the immune system. These drugs perform the same function as their endogenous counterparts. Data sources include ibm watson micromedex updated 1 apr 2021, cerner multum updated 5 apr 2021, ashp updated 6 apr 2021. Normal hematopoiesis is a wellregulated process in which the generation of mature blood.
These drugs are further subclassified into three groups based on their effect on the length of the action potential qt interval, figure 3. Belantamab mafodotin belantamab is also an antineoplastic. See the 2012 hematopoietic manual released in february 20, appendix e for a complete listing of the obsolete codes, their effective dates and the code the disease should now be assigned to. Eicosanoid regulation of hematopoiesis and hematopoietic. The diverse array of hematopoietic cells circulating within the. Impacts of drugs on neurotransmission national institute on.
Cardiovascular and hematopoietic drug treatment jody fraser 23 case study cardiovascular and hematopoietic drug treatment january 19, 2019 southern new hampshire university consider the following scenario. Most of these drugs require that the dosage be gradually decreased to prevent precipitation or worsening of adverse effects. Which medications in the drug class hematopoietic growth. These drugs perform the same function as their endogenous. Pdf morbidity is increased in patients undergoing hematopoietic stem cell transplantation when drug drug interactions lead to unexpected outcomes.
Which medications in the drug class hematopoietic growth factors. The hematopoietic growth factor epoetin alfa epogen, procrit is the prototype recombinant form of human erythropoietin that helps the body make more rbcs. Mcq pharmacology receptor antagonist drug metabolism. As you might expect, these drugs are potentially dangerous because they. The cells of the hematopoietic system are functionally diverse table 451. Meth is a highly addictive drug with potent central nervous system cns stimulant properties. While hsc based drugs can regenerate the hematopoietic system in. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Production and mechanism of action of hematopoietic growth. There is substantial redundancy in the spectra of activity of hematopoietic growth factors in that several individual factors may act on mature and immature cells of several lineages and there are several factors that have overlapping spectra of activity. Pdf the hematopoietic system in the context of regenerative. Drug therapy for hematopoietic disorders and to enhance. On the contrary, the effects of ace inhibitors aceis, at1 receptor blockers arbs, calcium channel blockers ccbs, and diuretics on sns function remain controversial. Hematopoietic colonystimulating factors csfs have been shown to reduce the duration and severity of neutropenia and the risk of febrile neutropenia and enable delivery of more intensive or dosedense chemotherapy when indicated.
Hematopoietic growth factorsgrowth factors are used to treat anemia of ckd by stimulating red blood cell rbc production. Ovarian cancer pancreatic cancer peripheral tcell lymphoma primary central nervous system lymphoma primary cutaneous lymphomas prostate cancer. What are the roles of hematopoietic stem cell transplantation. Disorders of the hematopoietic system springerlink. Blood is composed of the liquid component of plasma, and the solid components, which are mainly erythrocytes, leukocytes, and thrombocytes. The hematopoietic system consists of the bone marrow and the cells it produces, including leukocytes, erythrocytes, and thrombocytes. Scribd is the worlds largest social reading and publishing site. Bone marrowanticancer drugshematopoietic stem cell. Proper use of hematopoietic progenitor cells, cord blood.
Notify the primary health care provider promptly if adverse drug reactions occur. Pharmacology of hematopoiesis and immunomodulation. Learn pharmacology hematopoietic 1 with free interactive flashcards. Hematinics vitamin b is essential for dna synthesis.
Request pdf hematopoietic agents hematopoesis is a lifelong process. Blood cells and hematopoietic system customnursingessays. Csf is a hematopoietic growth factor which stimulates proliferation and differentiation of hematopoietic progenitor cells. This measure is curative because the hematopoietic system of the patient is replaced by that of the donor. The action of many nonsteroidal antiinflammatory drugs, which block the production of pge 2, may also act by increasing signaling via endocannabinoids. Case study cardiovascular and hematopoietic drug treatment. For convenience it is often divided into discrete systems even though there are extensive interactions. Breene lived a sedentary life as a clerk in a small insurance company. Therefore, drugs acting on the hematopoietic system would pertain to drugs that act on the blood producing system. The hematopoietic system is a prime example of successful applied regenerative. The hematopoietic system consists of organs and tissues, primarily the bone marrow, spleen, tonsils, and lymph nodes involved in the production of blood mosby company, 2016. The highly proliferative nature of bone marrow makes it a target for toxicants that preferentially attack rapidly dividing cells.
Eicosanoid regulation of hematopoiesis and hematopoietic stem. Although other factors act in addition to, or synergistically with, epo, the. These potential cis or transacting sites would have been undetected by. We used singlecell mass cytometry to examine healthy human bone marrow, measuring 34 parameters simultaneously in single cells binding of 31 antibodies, viability, dna content, and relative cell size. Those used to prevent or dissolve blood clots are divided into three classes that describe their mechanisms of action. The cns is responsible for processing and controlling most of our bodily functions, and consists of the nerves in the brain and spinal cord. Burgers medicinal chemistry, drug discovery and development. Development of the hematopoietic system hematopoiesis the process through which blood cells are made upload one day development of hematopoietic system. This shows that the drug is a human monoclonal antibody acting against tumors. The distinctions, however, are useful particularly for physicians and researchers.
The hematopoietic system includes the formed elements of the blood as well as the bone marrow, spleen, lymph nodes, and reticuloendothelial tissue. Central nervous system agents are medicines that affect the central nervous system cns. Hematopoietic progenitor cells, cord blood is given through a needle placed in one of your veins. These different classification systems can be confusing, since each drug may be included in multiple classes. Jul 23, 2016 chapter 17 hematopoietic drugs classification of hematopoietic drugs minerals ferrous sulfatea iron dextranb vitamins folic acid cyanocobalamin vitamin b12, calomist, nascobal hydroxocobalamin vitamin b12, cyanokit hematopoietic growth factors epoetin alfa epogen, procrit epoetin beta mircera darbepoetin alfa aranesp filgrastim neupogen. However, so far, none of the nephroprotective agents was approved for standard use. Bone marrow stem cell protection from chemotherapy by low. In closure, indeed the hematopoietic system is a broad and sensitive topic that requires more attention for proper understanding. Hematopoietic drugshematopoietic drugs introduction. Shortterm and longterm effects of drugs at receptors 1. Leukine sargramostim is a recombinant human granulocyte. Pegfilgrastim is a long acting filgrastim created by the covalent conjugate of recombinant granulocyte colonystimulating factor ie. Drugs acting on the immune system pharmacology education. Hematopoietic tissue is highly active susceptible to insults bone marrow and blood cells.
Briefly describe hematopoietic and immune functions. Specifically, hematopoietic medications increase the production of erythrocytes or red blood cells, leukocytes or white blood cells, and platelets, which are small clot forming fragments of a larger cell called a megakaryocyte. In this act, unless there is anything repugnant in the subject or context, 7 a. Singlecell mass cytometry of differential immune and drug.
Drugs used for iron deficiency anemia ferrous sulfateferrous gluconate ferrous fumarate drugs that are not. Drugs affecting hematopoiesis johns hopkins university. Melatonin and the immunehematopoietic system therapeutic and. Allogeneic hematopoietic transplantation for multiple myeloma. Inhibiting stat3 signaling in the hematopoietic system. For the 2014 changes, all these codes are now obs as of 2010.
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